Thu Dau Mot University Journal of Science

Target prediction and functional annotation analysis for potential microRNAs associated with Glioma

By Nguyen Bang Phi, Vo Hoang Xuan Dat
DOI: 10.37550/tdmu.EJS/2022.04.358


Glioma is a deadly tumor that accounts for the majority of malignancies of the brain and central nervous system. Currently, applying biomarkers and combining with clinical treatments in the diagnosis and prognosis of Glioma is the optimal trend. Among the effective biomarkers, microRNA has emerged as a novel, efficient biomarker. In this study, we used data from the Kyoto Encyclopedia of Genome and Gene Routes Database (KEGG) and bioinformatics tools for functional prediction and annotation of two Glioma-associated molecules (miR-6780a-5p and miR-6754-3p). The result indicated that 361 genes relating with two molecules miR-6780a-5p and miR-6754-3p. In which, miR-6780a-5p interacts with 198 genes and miR-6754-3p interacts with 166 genes. PPI analysis (protein-protein interaction analysis) and functional enrichment analysis revealed that target molecules of two miRNAs (miR-6780a-5p, miR-6754-3p) belong to cancer signaling pathways such as MAPK (Mitogen-activated protein kinase) and WNT (Wingless-related integration site). In addition, two miRNAs (miR-6780a-5p and miR-6754-3p) affect not only Glioma but also regulation in many other cancers such as pancreatic, thyroid, and endometrial cancer. Briefly, the result has clarified the role of (miR-6780a-5p, miR-6754-3p) in regulating signaling pathway of Glioma, thereby evaluating the interaction between miRNAs, target genes and target signaling pathways, and also supporting for the selection of potential biomarkers in Glioma diagnosis

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Publication Information


Thu Dau Mot University, Viet Nam

Honorary Editor-in-Chief and Chairman of the Editorial Board

Assoc. Prof. Nguyen Van Hiep

Deputy Editor-in-Chief

PhD. Trần Hạnh Minh Phương
Thu Dau Mot University

Editorial Board

Prof. Tran Van Doan
Fujen University, Taiwan
Prof. Zafar Uddin Ahmed
Vietnam National University Ho Chi Minh City

Prof.Dr. Phillip G.Cerny
The University of Manchester, United Kingdom
Prof. Ngo Van Le
University of Social Sciences and Humanities (VNU-HCM)

Prof. Bui The Cuong
Southern Institute of Social Sciences​​​​​​​
Prof. Le Quang Tri
Can Tho University

Assoc. Prof. Nguyen Van Duc
Animal Husbandry Association of Vietnam
Assoc. Prof. Ted Yuchung Liu
National Pingtung University, Taiwan

PhD. Anita Doraisami
Economics Monash University, Australia
Prof. Dr. Andrew Seddon
Asia Pacific University of Technology & innovation (APU)

Assoc. Prof. Le Tuan Anh
Thu Dau Mot University
Prof. Abtar Darshan Singh
Asia Pacific University, Malaysia

Prof.Dr. Ron W.Edwards
The University of Melbourne, Australia
Assoc. Prof. Hoang Xuan Nien
Thu Dau Mot University

PhD. Nguyen Duc Nghia
Vietnam National University Ho Chi Minh City
PhD. Bao Dat
Monash University (Australia)

PhD. Raqib Chowdhury
Monash University (Australia)
PhD. Nguyen Hoang Tuan
Thu Dau Mot University

PhD. Nguyen Thi Lien Thuong
Thu Dau Mot University


Nguyen Thi Man
Thu Dau Mot University