Primates play a huge role in biomedical research. They are raised for medical research and to test new vaccines before being used for humans. The yellow-cheeked gibbon (Nomascus gabriellae) is an endemic mammal of Vietnam, included in the Vietnam Red Book 2007, and described in the IUCN Red Book 2009. This species is an endangered species found only in a small region of Indochina, and its populations have declined in most known sites. The purpose of this article is to present an overview research on taxonomy, identification, reproduction, behavior, ecology, distribution, population, and conservation status of this species. The overall results are intended to support the conservation of this rare endemic animal species and provide reference in related biomedical research.