The objective of this study was to determine iodine levels in soils, grains, and goitrogenic content of common grains across zones of Sokoto state, Nigeria using standard methods and reagents of analytical grade. Obtained data were subjected to descriptive and ANOVA statistics. The Western zone has highest iodine (29±0.01ppm), followed by Central zone (26±0.01ppm), and last was East Zone (24±0.01ppm). The factors that affect iodine bioavailability such as pH and organic matter were determined in different soils of Sokoto (Table 1). East zone had the most elevated pH (6.55±0.08), followed by Central Zone (6.17±0.06) and lastly (5.82±0.05). However, organic matter was most elevated in EZ (5.4±0.01%), CZ (4.5±0.05), and lastly WZ (3.4±0.02). Iodine level in Rice (25±0.014ppm) was significantly higher (P