Based on research methods such as methods such as data collection and processing, air quality index calculation methods, public health risk assessment methods to assess air quality and effects of substances on the health of people in Di An city. The data for the calculation are inherited from the environmental monitoring report of the Department of Natural Resources and Environment of Di An city in the period of 2019. The calculation results show that the air quality in the city. Di An is fluctuating at an average - poor level (especially in the Cay Lon junction area with the highest index of 150), the health risk assessment results show that when exposed to dust, the total group of people Adults (Women and Men) had a high fluctuating cancer risk index with the highest index of 2 subjects being in the first quarter 0.310, 0.295, in the second quarter 0.269, 0.282, in the third quarter 0.296, 0.282, Fourth quarter 0.289, 0.275. As for other indicators, the subjects assessed when exposed to substances in the air environment in Di An city can be affected to their health, of which the group of adults is still the group of people. Women and men) are the most affected group.