The Southeast region, in prehistory and protohistory, established the space of Dong Nai archeological culture. Since the 16th to 17th centuries, the Southeast had been discovered by the Vietnamese people, in which they established sovereignty and administrative structure. Over three centuries of formation and development, the Southeast region has created many changes in geographic names and administrative structures as required by the historical context of each period. This article presents the overview of the administrative restructuring process in the Southeast region in some important historical milestones during the development process hereof. With the presentation of administrative structures in the Southeast region, the article contributes to systemizing the historical periods of formation and development of the region. It also opens further dialogues for the study of historical and cultural characteristics of the Southeast region.