In Vietnam, deviant behaviour in adolescents is increasingly popular and gradually becomes a major concern of the whole society. The purpose of this study is to identify Factors affecting deviant behavior of Vietnamese adolescents, including: Nature of adolescence (Biology, Intelligence and Cognitive functions) and Nurture (Family atmosphere, Education environment, Media and technology, Peer Pressure, and Religion and Politics). 426 survey samples were collected to serve the data analysis process as well as all hypotheses were examined by using STATISTIC 10 ver., LISREL 8.8 with Covariance Matrix, and LISREL model. This research showed that Nature of adolescence, Family atmosphere, Education environment, Social media and technology, Peer pressure have significant influence on deviant behavior of adolescents in Vietnam. The research also indicated that deviant behavior of Vietnamese adolescents is not affected by Religion and politics. The study also makes suggestions to improve morality and foster personality for adolescents in Vietnam, makes a small contribution to the country's further development.