Industrial Revolution 4.0 has become an indispensable trend in the development process of Vietnam and is increasingly applied in university education. The essence of the Industrial Revolution 4.0 is the application of technology, data science and the use of artificial intelligence for production and human life. In this impact, modern education, especially higher education, is the field most affected. Online teaching, with tools to support the teaching of the digital age, has been changing dramatically in the teaching and learning situation in universities, helping to modernize education and integrate with the world, but there are many issues that teachers and managers must consider to change teaching methods and training strategies, in order to deliver the best results. Starting from the actual situation, we propose specific and comprehensive measures to improve the teaching efficiency of Thu Dau Mot University and, to meet the needs of Vietnamese society and the development of Industrial Revolution 4.0.